Glucagon
نویسندگان
چکیده
منابع مشابه
Glucagon antibodies and an immunoassay for glucagon.
Despite extensive knowledge of the amino acid composition of beef-pork glucagon, and of the physiologic changes induced by its administration to animals and man, the role of glucagon in the homeostatic regulation of blood glucose level in normal and abnormal states remains to be defined. This fundamental gap in knowledge is the result of the lack of a method sufficiently specific and sensitive ...
متن کاملGlucagon and glucagon-like peptide receptors as drug targets.
Glucagon and the glucagon-like peptides are derived from a common proglucagon precursor, and regulate energy homeostasis through interaction with a family of distinct G protein coupled receptors. Three proglucagon-derived peptides, glucagon, GLP-1, and GLP-2, play important roles in energy intake, absorption, and disposal, as elucidated through studies utilizing peptide antagonists and receptor...
متن کاملPlasma pancreatic glucagon and insulin: glucagon ratio at birth.
of delivery (14) the mean (±SE) plasma concentration of glucose was 99±7 mg/100 ml, insulin 32±6 ,uU/ml, glucagon 183±17 pg/ml. These levels were similar to those occurring in mothers who did not have an i.v. infusion, permitting pooling of the two groups for further analysis. The 't' test for paired data was used for statistical comparison of plasma concentrations of metabolite or hormones. Th...
متن کاملA novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.
Glucagon maintains glucose homeostasis during the fasting state by promoting hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated glucagon-to-insulin ratio have been reported in diabetic patients and animals. Antagonizing the glucagon receptor is expected to result in reduced hepatic glucose overproduction, leading to overall glycemic control. Here we report the disc...
متن کاملGlucagon-like Peptide-2.
Multiple peptide hormones produced within the gastrointestinal system aid in the regulation of energy homeostasis and metabolism. Among these is the intestinotrophic peptide glucagon-like peptide-2 (GLP-2), which is released following food intake and plays a significant role in the adaptive regulation of bowel mass and mucosal integrity. The discovery of GLP-2's potent growth-promoting and cyto...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1969
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.25.2.183